The human chronobiome refers to the collection of biological rhythms that regulate physiology, metabolism, and behavior. It integrates circadian clocks, molecular oscillations, and environmental cues to maintain temporal homeostasis and synchronize internal processes with the external environment.
Postoperative clinical care is prone to circadian desynchronization that, in turn, may influence health outcomes. We are currently developing paradigms at the University of Pennsylvania Hospital Systems to quantify sleep-wake rhythms with digital technologies. Preliminary data from a recent pilot study will inform the design of a controlled trial seeking to modify circadian/diurnal disruptors to enhance patient outcome. Data and analysis are available here.
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